Semaglutide Raw Powder CAS 910463-68-2

Semaglutide is a new generation of GLP-1 (glucagon-like peptide-1) analog that stimulates insulin secretion in a glucose-dependent manner and can be used to treat type 2 diabetes. The long-acting mechanism of Semaglutide is based on structural modification, which involves attaching an 18-carbon fatty acid side chain to the lysine position of the peptide chain at position 26. The modified carbon chain increases the molecular weight of Semaglutide and enhances its affinity for albumin by 5 to 6 times, preventing rapid clearance by the kidneys and metabolic degradation, thus prolonging its half-life in the body.

Semaglutide is a long-acting glucagon-like peptide-1 receptor agonist (GLP-1RA) with 94% amino acid sequence homology to natural human glucagon-like peptide-1. As the sixth marketed GLP-1RA drug and the third once-weekly long-acting formulation, it is mainly used for glycemic control in adult patients with type 2 diabetes.

Professor Wei Guohong of the Department of Endocrinology at the First Affiliated Hospital of Sun Yat-sen University explained to reporters that the main mechanism by which Semaglutide can achieve blood sugar reduction and weight loss is that it can promote insulin secretion in a glucose concentration-dependent manner by activating GLP-1 (glucagon-like peptide-1) receptor, inhibit glucagon secretion, delay gastric emptying and increase satiety, and suppress appetite by inhibiting the function of the hypothalamic feeding center, thereby achieving the effect of blood sugar reduction and weight loss.

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